Here, we look at two potential polymeric carriers, chitosan and poly(amidoamine) dendrimers, which have been widely reported for gene delivery. For chitosan ...
Gene therapy has grown very rapidly because of its tremendous therapeutic potential to cure numerous genetic diseases by the insertion of new ...
Approximately 4000 diseases are associated with malfunctioning genes in a particular cell type. Gene-based therapy provides a platform to modify the ...
(1) As the primary type of nonviral gene-delivery carriers, cationic polymers possess low host immunogenicity and can be produced massively.
The development of vectors for cell-specific gene delivery is a major goal of gene therapeutic strategies. Significant progress has been made in the construction ...
Results. All the carriers were able to complex DNA. The highest, comparable to commercial reagents, transfection efficiency was observed for ...
At present, it is widely accepted that the success of gene therapy and genetic vaccination depends strongly on the design of a carrier that could ...
Gene therapy has captured the attention of scientists around the world to overcome genetic diseases such as cancers, diabetes, multiple ...
Specific delivery and efficient release of genetic materials from their carriers are prerequisites for an effective therapy. Specific delivery/targeting could be achieved ...
Instead, a carrier called a vector is genetically engineered to deliver the gene. Certain viruses are often used as vectors because they can ...