Efficient Payload Delivery by a Bispecific Antibody-Drug Conjugate Targeting HER2 and CD63. Mol Cancer Ther. 2016 Nov;15(11):2688-2697.
Currently, five bsAbs delivering payloads are in clinical trials, four of which target solid tumors. BsAb TF2, existing of three Fab fragments of which two target CEA ...
... monoclonal antibodies for delivery of cytotoxic payloads to cancer cells
1a), but also Fab or single-domain Ab (sdAb)) held together by a peptide linker,
The tumor signaling perturbation through antibody interference has
They bound cotinine to the anti-cancer drug duocarmycin, then
Complexed payloads are targeted by the bispecifics to cancer cells and
A new paradigm for an effective delivery of therapeutics into cancer cells is presented.
cell killing mechanisms, payload delivery, and specific effects of an antibody on the.
Triple-negative breast cancer (TNBC), an aggressive subtype of breast cancer, is difficult